MidWest Drug Development Conference
Downtown Capitol District, Omaha, Neb. | Oct. 4-5, 2021
2021-10-04 08:00:00
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Antimicrobial Peptides Targeting Intracellular Bacteria

Purdue University

Researchers at Purdue University developed antimicrobial agents against intracellular human pathogens with improved efficacy compared to the group’s previous-generation compounds. Drug resistant bacteria are an increasing worldwide threat, especially in the healthcare environment. Compounding the threat, many bacterial species localize within human cells.

Designing and formulating drugs to reach inside host cells without damaging those cells is a key challenge in treating bacterial infection. The Purdue team employs cell-penetrating peptides to meet this challenge. Their newest generation of peptide-based compounds compares well to vancomycin and gentamicin, in some cases outperforming the established antibiotics in cell culture. The Purdue peptides also demonstrate excellent cell penetrating ability and safety against human cells.

Advantages:

  • Penetrates human cells to target intracellular pathogens
  • Effective alone or as a covalent conjugate with other antibiotics
  • Avoids use of delivery vehicles

Potential Applications:

  • Antibiotic therapeutic
  • Pharmaceuticals

Intellectual Property:

  • US Patent No. 10,875,895 (Issued 12/29/20)

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MIDWEST DRUG DEVELOPMENT CONFERENCE
Bringing together industry and the best university drug development researchers in the Midwest
Downtown Capitol District, Omaha, NE
Oct. 4-5, 2021

Latest News
  • Registrations are now open for 2021 March 25, 2021
  • Planners set initial slate of participants, more to come February 22, 2021
  • MidWest Drug Development Conference plans to return in 2021 January 11, 2021
  • MidWest Drug Development Conference for 2020 is postponed July 15, 2020
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