Water soluble glucagon derivative stable at neutral pH
A method of stabilizing glucagon and improving its solubility in aqueous form.
Glucagon is a 29 amino acid peptide hormone used to treat severe hypoglycemia, typically in diabetic patients. Glucagon is typically marketed in lyophilized, or freeze-dried form, as it is unstable in acidic or basic aqueous solutions, which inhibits its use in medical devices such as pens or pumps. As a result, the delivery process is complicated, particularly in emergencies.
To address these concerns, researchers at Purdue University have developed a method of stabilizing glucagon and improving its solubility in aqueous form. As a result, glucagon can be used in numerous applications such as pen devices and pumps, and even as an artificial pancreas. Because the technology uses a phosphate ester prodrug approach, it expected to have no biological activity in the derivative form, and will only be active when the native drug is regenerated. This technology is superior to alternative approaches in that the native, active sequence of glucagon is regenerated once administrated.