MidWest Drug Development Conference
Downtown Capitol District, Omaha, Neb. | Oct. 4-5, 2021
2021-10-04 08:00:00
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Mps1/TTK kinase inhibitor to treat hematological malignancies

Ohio State University

The TTK kinase is critical for proper function of the spindle assembly checkpoint, and its upregulation is associated with poor clinical outcomes in a variety of cancer types. TTK kinase inhibition in cancer cells, especially those featuring significant chromosomal instability, leads to aneuploid phenotypes incompatible with cell viability.

The Ohio State University’s Drug Development Institute (DDI) is developing an orally bioavailable, brain penetrant small molecule inhibitor of TTK. Highlighting efficacy of our lead compound in multiple in vivo tumor models, as well as ongoing lead characterization and optimization, the DDI will report on progress toward selection of a preclinical candidate.

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MIDWEST DRUG DEVELOPMENT CONFERENCE
Bringing together industry and the best university drug development researchers in the Midwest
Downtown Capitol District, Omaha, NE
Oct. 4-5, 2021

Latest News
  • Registrations are now open for 2021 March 25, 2021
  • Planners set initial slate of participants, more to come February 22, 2021
  • MidWest Drug Development Conference plans to return in 2021 January 11, 2021
  • MidWest Drug Development Conference for 2020 is postponed July 15, 2020
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