Novel peptides for therapeutic treatment of injury related to ischemia/reperfusion
Therapeutic peptides to combat excessive inflammation and tissue damage in response to ischemia/reperfusion (IR).
Reperfusion (the return of blood flow) significantly magnifies ischemia (lack of blood flow) induced tissue damage in multiple clinical conditions including myocardial infarction, trauma and hemorrhage. During reperfusion, antibody recognition of endogenous damage-associated proteins, is followed by an excessive inflammatory response frequently resulting in multiple organ failure and death.
Although multiple intracellular antigens are recognized by the antibodies, β2-glycoprotein I (β2-GPI) is the only known serum protein recognized by the naturally occurring antibodies. Antibody binding to membrane-bound β2-GPI leads to an excessive inflammatory response resulting in tissue damage. Development of peptides which compete for the β2-GPI cell surface receptor is a logical approach for developing candidate therapeutics. β2-GPI also is critical to formation of new blood vessels in tumors suggesting the peptides under development at K-State may also decrease tumor growth.