Sensory neuron actin remodeling, a new paradigm in pain therapeutics
University of Nebraska-Lincoln researchers are developing a novel protein based delivery technology that targets sensory neurons to stop pain signals at the source to avoid systemic toxicity and addiction potential.
Up to 100 million Americans suffer from conditions with chronic pain, causing limited mobility, increased isolation, and reduced life quality. Chronic pain was once frequently treated with opioids, but these drugs are no longer viable for most patients. Other current treatments are largely small molecules with systemic effects like addiction and somnolence. New treatments are needed.
Animal research findings show that N-001 provides the same pain relief as opioids, but lasts three times longer.