MidWest Drug Development Conference
ONLINE EVENT | Oct. 4-5, 2021
2021-10-04 08:00:00
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New approach improves CAR T cancer therapies

Mayo Clinic

Mayo Clinic researchers have developed a novel regimen by which oncolytic virotherapy can be used as a potent immunological adjuvant to improve the efficacy of CAR T cell therapy against solid tumors.

Experiments have shown that CAR T cells loaded ex vivo with oncolytic virus (OV) induces a population of CAR T cells with dual specificity against the CAR target tumor antigen and oncolytic viral antigen(s) in vivo, which have improved memory-like differentiation, persistence, and greatly enhanced anti-tumor potency compared to conventional CAR T cells.  Mayo researchers have generated dual specific CAR T (DS CAR T) cells with TCR specificity against either viral, or tumor associated, antigens and have optimized the persistence/longevity/activity of DS CAR T cells through novel boosting strategies, leading to implementation of clinically simple, fully systemic protocols for the combination of CAR T cells with OV which do not require any access to tumors.

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MIDWEST DRUG DEVELOPMENT CONFERENCE
Bringing together industry and the best university drug development researchers in the Midwest
An Online Event
Oct. 4-5, 2021

Latest News
  • Presentation schedule set for 2021 September 21, 2021
  • MWDD moves to a virtual event in 2021 August 17, 2021
  • Sponsorship, presentation slots nearly full July 29, 2021
  • Registrations are now open for 2021 March 25, 2021
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