The search for better analgesics has focused on non-addictive alternatives. Agmatine, the decarboxylated product of arginine, is a potential candidate for novel therapeutics.

Researchers at Purdue University developed antimicrobial agents against intracellular human pathogens with improved efficacy compared to the group’s previous-generation compounds.

Researchers at the University of Oklahoma have discovered a class of antitoxin peptides that inhibit a critical clostridium difficile virulence factor.

Dihydroorotate dehydrogenase (DHODH) is a key enzyme in the de novo pyrimidine synthesis pathway.

A dual diagnostic and therapeutic compound binds GRPr and PSMA with high specificity and sensitivity.

Novel dual- and tri-AAV hybrid vector systems increase the upper size limit of gene constructs from <5kb to <15kb.

SerpinB13 is a protease inhibitor linked to autoimmune inflammation and Type 1 diabetes (T1D).

The TTK kinase is critical for proper function of the spindle assembly checkpoint, and its upregulation is associated with poor clinical outcomes in a variety of cancer types.

Inventors at the University of Iowa have developed a respiratory syncytial virus vaccine. It is a nanovaccine consisting of viral proteins encapsulated by biodegradable polyanhydride polymers.

A new hybrid nanocapsule uses a silica, metal and organic framework designed to deliver protein, nucleic acid or hydrophilic drugs.

This technology uses 2-deoxy-D-glucose (2DG) as a novel treatment for Status Epilepticus (SE).

Post-traumatic osteoarthritis weakens the regulation of lubricin gene and increases shear stress within the joints.

Researchers at the University of Missouri have developed novel inhibitors of beta-lactamase, a bacterial enzyme that provides resistance to β-lactam antibiotics.

The researchers of the University of Colorado developed a series of hydroxamic acid derivatives as HDAC6 selective inhibitors.

A new formulation of paclitaxel fuses the drug to an oligo-lactic acid (oLA) encapsulated in a PEG-PLA micelle.

Bioactive synthetic peptides derived from neutrophil proteins, cathepsin G and CAP37, can inhibit and reverse the formation of toxic amyloid beta aggregates.

Persephacin, a novel fungal isolate, strongly inhibits a broad range of pathogenic fungi while exhibiting low cytotoxicity to mammalian cells.

Using C. elegans as an animal model to study radiation-induced bystander effects (RIBE), researchers at the University of Colorado Boulder have identified a highly conserved cysteine protease, cathepsin B, as the first RIBE factor.

Endometrial cancer is the most frequent gynecological cancer and is often treated using platinum-based therapies such as cisplatin.

The estrogen receptors, alpha and beta, are both responsive to endogenous estrogen, but modulate different biological processes.

Researchers at Purdue University have developed a targeted therapeutic option for treating metastatic prostate cancer, the second leading cause of cancer death for men in the United States.

Researchers at Purdue University have developed an immunotherapy approach combining cell therapy and a small molecule inhibitor to treat glioblastoma.