Survivin is an ideal target for discovery of anticancer drugs because it is expressed only in cancers but not adult human tissues.

Antibiotic gel formulations, including low concentrations of two antibiotics, are capable of killing root canal pathogens without harming the stem cells inside the root canal.

Sphingosine 1-phospate metabolizing enzymes are involved in modulating cellular responses to a variety of viruses in human and veterinary applications. 

Stable derivatives of naturally occurring endocannabinoid epoxides that produce some of the same medicinal qualities as marijuana

A proprietary high-throughput screening method to identify and characterize in-cell based assays compounds that inhibit FATP2 mediated fatty acid uptake.

Combination of Proton Pump Inhibitors (PPIs) Omeprazole and Lansoprazole in a buffered composition for 24-hour gastric pH control to treat a variety of acid-related disorders such as Barrett’s Esophagus, Gastroesophageal Reflux Disease, and others. 

This transformative initiative focuses on the development and clinical introduction of a first-in-class drug to safely and effectively treat early stage fatty liver disease.

Novel estrogens that retain beneficial effects in metabolic tissues without further risks to reproductive tissues

Pioglitazone, currently approved for treatment of diabetes under the trade name Actos, is effective in delaying cyst growth in polycystic kidney disease (PKD). 

A scaling-up method for producing drug nanocrystals that combines the top-down and bottom-up approaches.

T cell interactions with specific receptors/ligands on lymphatic endothelium are necessary for the egress of T cells from peripheral lymph nodes into the circulation.

More details coming soon!

Metformin, a naturally-occurring biguanide, is an FDA-approved high-safety profile diabetes drug that has been used extensively for decades.

InnoBioPharma has developed several novel drug candidates (two in pre-clinical trials) that are particularly effective against aggressive cancers that lack effective drug therapy.

A molecule capable of specifically inhibiting the NF-κB pathway, a key target involved in a variety of cancers and other diseases.

An effective method of treatment for chronic and inflammatory pain by inhibiting selective adenylyl cyclases, especially adenylyl cyclase 1. Compounds may also prevent and/or reduce opioid dependence.

Peptide-based therapeutic agents that inhibit the CAPN5 enzyme.

Novel inhibitors targeting 3C or 3CL virus proteases.

Cancers persist only when they evade the host’s immune system.  This novel cancer therapy resensitizes the host immune system to cancer epitopes through a novel method involving vaccination with a treated sample of the biopsied tumor.  Trials in canines have demonstrated efficacy.  Patents pending.

Wet age-related macular degeneration (AMD) is known to negatively affect aging populations. The disease can result in blindness and can lead to a severe decline in quality of life.

A substrate mediated delivery system for highly controlled local and sustained release of any hydrophobic or hydrophilic cargo.

Therapeutic peptides to combat excessive inflammation and tissue damage in response to ischemia/reperfusion (IR).

Cell-specific non-toxic reagent for the treatment of hematological and other cancers. Data using micelles composed of peptide amphiphiles targeted using aptamers demonstrate efficacy against a wide range of human and canine cancers, as well as low toxicity in vivo, and 2-3x longer median survival.  Patents issued and pending.

A therapeutic vaccine for patients with recurrent prostate cancer that effectively destroys expressing tumor cells while leaving normal cells unharmed.

A collaboration between Kansas State University and Wichita State University has led to the development of protease inhibitors with improved pharmacokinetics (PK) and bioavailability using a prodrug approach of peptidyl aldehyde compounds.

More info coming soon!

In humans, there are two nearly identical copies of the Survival Motor Neuron (SMN) gene, SMN1 and SMN2.  Loss of SMN1 in conjunction with skipping of SMN2 exon 7 in pre-mRNA splicing—which results in a truncated, unstable SMN—leads to spinal muscular atrophy. 

This talk will focus on the design, synthesis, and study of ligands that target DNA and RNA repeat sequences that cause disease.

Combination treatment of Ig-GAD2 and stem cells to cure Type I Diabetes (TID).  Data demonstrate a functional cure in a mouse model for TID through restoration of immune tolerance coupled with regeneration of endothelial cells in the pancreatic islets. Patents issued and pending.

Azaindenoisoquinoline compounds that act as inhibitors of Top1, TDP1, and TDP2 for cancer treatment

TR3 Technology delivers a new generation of TNF superfamily TRAIL (TNF-related apoptosis-inducing ligand, designated TR3) directly to MUC16-expressing cancer cells.

More info coming soon!

Prostate Cancer (PC) is commonly treated with androgen deprivation therapy (ADT), but tumors may become resistant to androgen removal and are then categorized as Castration-Resistant PC (CRPC).

LoDos Theranostics has developed “first-in-class” nanoparticles called “Radio-Luminescent Nano Particles (RLNPs)” which will be injected into the tumor before a patient receives radiation treatment: The first product to endogenously deliver UV light to deep tumors.