MidWest Drug Development Conference
ONLINE EVENT | Oct. 4-5, 2021
2021-10-04 08:00:00
Register!
Downloads
  • 2021 Program
  • Flyer
  • 2021 Schedule
  • 2019 Program
  • 2018 Program
  • Map & Other Info (Coming soon!)
  • Home
  • Schedule
  • Venue
  • Technologies
    • Categories
    • Institutions
    • Startups
    • Previous Technologies
  • Sponsors
  • News
  • Contact
  • Home
  • Schedule
  • Venue
  • Technologies
    • Categories
    • Institutions
    • Startups
    • Previous Technologies
  • Sponsors
  • News
  • Contact

Small molecule Wnt modulators to treat Alzheimer’s

Mayo Clinic

Mayo Clinic researchers have developed a small molecule modulator for use in treating and preventing a variety of Wnt-related conditions such as Alzheimer’s Disease (AD) and other neurodegenerative disorders, traumatic and ischemic brain injury, as well as bone loss disorders.

Wnt/β-catenin signaling is crucial for synaptic plasticity, neuronal survival, and neurogenesis. Relevant to AD, activation of Wnt/β-catenin signaling inhibits Aβ production and tau hyperphosphorylation, two events central to the pathogenesis of AD. Critically, Wnt/β-catenin signaling is greatly suppressed in AD brains through multiple pathogenic mechanisms. As such, restoring Wnt/β-catenin signaling represents an attractive strategy for the rational design of novel AD therapies. In preliminary studies, a series of novel Wnt modulators have been developed. The lead compounds display great potency (EC50< 500 nM) in activation of Wnt/β-catenin signaling, good pharmacokinetic profiles with high oral bioavailability and brain penetration.  Importantly, the lead modulator W2A-16 significantly suppresses tau phosphorylation and improves cognitive function in the Alzheimer mouse models. Moreover, W2A-16 greatly prevents body weight loss and enhances the survival ofPS19 tau transgenic mice.

Logo

MIDWEST DRUG DEVELOPMENT CONFERENCE
Bringing together industry and the best university drug development researchers in the Midwest
An Online Event
Oct. 4-5, 2021

Latest News
  • Presentation schedule set for 2021 September 21, 2021
  • MWDD moves to a virtual event in 2021 August 17, 2021
  • Sponsorship, presentation slots nearly full July 29, 2021
  • Registrations are now open for 2021 March 25, 2021
Twitter Hightlights
  • Today's the day!
    491 days ago
  • Schedule is set for the 2021 MidWest Drug Development Conference. Register today! https://t.co/5SvzL4EhuV
    504 days ago
  • No surprise to see some incredible innovations out of @UWMadison that could change drug delivery approaches, cancer… https://t.co/h90yfHwC5k
    505 days ago

Follow us! @DrugMw