The TTK kinase is critical for proper function of the spindle assembly checkpoint, and its upregulation is associated with poor clinical outcomes in a variety of cancer types.

The estrogen receptors, alpha and beta, are both responsive to endogenous estrogen, but modulate different biological processes.

Dihydroorotate dehydrogenase (DHODH) is a key enzyme in the de novo pyrimidine synthesis pathway.

Researchers at Purdue University developed antimicrobial agents against intracellular human pathogens with improved efficacy compared to the group’s previous-generation compounds.

Researchers at Purdue University have developed a targeted therapeutic option for treating metastatic prostate cancer, the second leading cause of cancer death for men in the United States.

Researchers at Purdue University have developed an immunotherapy approach combining cell therapy and a small molecule inhibitor to treat glioblastoma.

Using C. elegans as an animal model to study radiation-induced bystander effects (RIBE), researchers at the University of Colorado Boulder have identified a highly conserved cysteine protease, cathepsin B, as the first RIBE factor.

The researchers of the University of Colorado developed a series of hydroxamic acid derivatives as HDAC6 selective inhibitors.

Inventors at the University of Iowa have developed a respiratory syncytial virus vaccine. It is a nanovaccine consisting of viral proteins encapsulated by biodegradable polyanhydride polymers.

Endometrial cancer is the most frequent gynecological cancer and is often treated using platinum-based therapies such as cisplatin.

Post-traumatic osteoarthritis weakens the regulation of lubricin gene and increases shear stress within the joints.

SerpinB13 is a protease inhibitor linked to autoimmune inflammation and Type 1 diabetes (T1D).

The search for better analgesics has focused on non-addictive alternatives. Agmatine, the decarboxylated product of arginine, is a potential candidate for novel therapeutics.

A dual diagnostic and therapeutic compound binds GRPr and PSMA with high specificity and sensitivity.

Novel dual- and tri-AAV hybrid vector systems increase the upper size limit of gene constructs from <5kb to <15kb.

Researchers at the University of Missouri have developed novel inhibitors of beta-lactamase, a bacterial enzyme that provides resistance to β-lactam antibiotics.

Researchers at the University of Oklahoma have discovered a class of antitoxin peptides that inhibit a critical clostridium difficile virulence factor.

Persephacin, a novel fungal isolate, strongly inhibits a broad range of pathogenic fungi while exhibiting low cytotoxicity to mammalian cells.

Bioactive synthetic peptides derived from neutrophil proteins, cathepsin G and CAP37, can inhibit and reverse the formation of toxic amyloid beta aggregates.

A new hybrid nanocapsule uses a silica, metal and organic framework designed to deliver protein, nucleic acid or hydrophilic drugs.

A new formulation of paclitaxel fuses the drug to an oligo-lactic acid (oLA) encapsulated in a PEG-PLA micelle.

This technology uses 2-deoxy-D-glucose (2DG) as a novel treatment for Status Epilepticus (SE).