MidWest Drug Development Conference
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2021-10-04 08:00:00
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New mitochondria-targeted therapeutics will help lung, other cancers

Medical College of Wisconsin

Medical College of Wisconsin inventors have developed novel small molecule therapeutics that will help treat small cell lung cancer, among other cancers. These new compounds, named “mito-honokiols” are selectively designed to accumulate in tumor mitochondria and inhibit OXPHOS via mitochondrial complex 1, which affords cytostatic properties against tumor cells, thereby inhibiting tumor growth and significantly reducing brain metastases.

Historically, mitochondria were thought to be dispensable in tumor cells. However, certain cancers are now known to be highly dependent on mitochondrial metabolism, making OXPHOS an emerging druggable target for cancer therapy. These new “mito-honokiol” compounds were designed with tumor-specific OXPHOS inhibition in mind, and have shown efficacy towards both in vitro cell line and in vivo mouse lung cancer models.

Key Advantages:

  • Selective to tumor cells with no toxicity to normal cells—even up to 20x effective dose
  • Nanomolar potency
  • Significantly reduces brain metastases in addition to inhibiting primary tumor growth

Applications: The “mito-honokiol” cytostatic compounds have significant potential as therapies alone or in combination with cytotoxic agents and/or immunotherapies.

 

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MIDWEST DRUG DEVELOPMENT CONFERENCE
Bringing together industry and the best university drug development researchers in the Midwest
An Online Event
Oct. 4-5, 2021

Latest News
  • Presentation schedule set for 2021 September 21, 2021
  • MWDD moves to a virtual event in 2021 August 17, 2021
  • Sponsorship, presentation slots nearly full July 29, 2021
  • Registrations are now open for 2021 March 25, 2021
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