MidWest Drug Development Conference
ONLINE EVENT | Oct. 4-5, 2021
2021-10-04 08:00:00
Register!
Downloads
  • 2021 Program
  • Flyer
  • 2021 Schedule
  • 2019 Program
  • 2018 Program
  • Map & Other Info (Coming soon!)
  • Home
  • Schedule
  • Venue
  • Technologies
    • Categories
    • Institutions
    • Startups
    • Previous Technologies
  • Sponsors
  • News
  • Contact
  • Home
  • Schedule
  • Venue
  • Technologies
    • Categories
    • Institutions
    • Startups
    • Previous Technologies
  • Sponsors
  • News
  • Contact

Prevent, alleviate side effects of radiation or radiotherapy

University of Colorado-Boulder

Using C. elegans as an animal model to study radiation-induced bystander effects (RIBE), researchers at the University of Colorado Boulder have identified a highly conserved cysteine protease, cathepsin B, as the first RIBE factor.

Radiation-induced bystander effects (RIBE) refer to a unique process, in which factors released by irradiated cells or tissues exert effects on other parts of the animal not exposed to radiation, causing genomic instability, stress responses, and altered apoptosis or cell proliferation. RIBE is a major factor in determining the efficacy and success of radiotherapy in cancer treatment. RIBE affects and causes damage in non-irradiated cells and tissues, resulting in all sorts of deleterious side effects that include hair loss, fatigue, skin problems, and low blood counts. RIBE can also affect irradiated cells through paracrine signaling and cause resistance of cancer cells to radiotherapy. Until now, there had been no effective way to reduce or prevent side effects caused by radiation and radiotherapy.

Cathepsin B is secreted from animals or cells irradiated with ultraviolet (UV) or ionizing gamma rays (IR) and is the major factor in the conditioned medium that leads to increased embryonic lethality in irradiated animals. Moreover, cathepsin B causes these effects and stress responses at unexposed sites distal to the irradiated tissue. The activity of cathepsin B is regulated by the p53 tumor suppressor gene in response to radiation and appears to act through the insulin like growth factor receptor and its downstream PDK kinase to exert RIBE.

Logo

MIDWEST DRUG DEVELOPMENT CONFERENCE
Bringing together industry and the best university drug development researchers in the Midwest
An Online Event
Oct. 4-5, 2021

Latest News
  • Presentation schedule set for 2021 September 21, 2021
  • MWDD moves to a virtual event in 2021 August 17, 2021
  • Sponsorship, presentation slots nearly full July 29, 2021
  • Registrations are now open for 2021 March 25, 2021
Twitter Hightlights
  • Today's the day!
    491 days ago
  • Schedule is set for the 2021 MidWest Drug Development Conference. Register today! https://t.co/5SvzL4EhuV
    504 days ago
  • No surprise to see some incredible innovations out of @UWMadison that could change drug delivery approaches, cancer… https://t.co/h90yfHwC5k
    505 days ago

Follow us! @DrugMw