MidWest Drug Development Conference
ONLINE EVENT | Oct. 4-5, 2021
2021-10-04 08:00:00
Register!
Downloads
  • 2021 Program
  • Flyer
  • 2021 Schedule
  • 2019 Program
  • 2018 Program
  • Map & Other Info (Coming soon!)
  • Home
  • Schedule
  • Venue
  • Technologies
    • Categories
    • Institutions
    • Startups
    • Previous Technologies
  • Sponsors
  • News
  • Contact
  • Home
  • Schedule
  • Venue
  • Technologies
    • Categories
    • Institutions
    • Startups
    • Previous Technologies
  • Sponsors
  • News
  • Contact

Vasculonics develops new therapy for acute kidney and chronic diabetic kidney disease with clinical candidates

Vasculonics (Indiana University)

Vasculonics is an Indiana-based biotech formed out of technology licensed from Indiana University.

Based on the novel discoveries of Dr. Jaipal Singh, Vasculonics is pioneering the development of therapeutics affecting the dimethylarginine dimethylaminohydrolase (DDAH) which reduces asymmetric dimethyl arginine (ADMA) and vascular pathology in kidney, heart and lungs (including pulmonary arterial hypertension).

Reduced levels of DDAH, common from stressors like diabetes, CV disease, and lung dysfunction, leads to the accumulation of high levels of ADMA.  ADMA has been identified as a major cause of reducing nitric oxide (NO) synthesis, induction of mitochondrial dysfunction, cell death, inflammation, and fibrosis.

Vasculonics has developed proof of concept (POC) that restauration of DDAH by administering exogenous DDAH is therapeutic. Vasculonics is also developing novel small molecules which enhance DDAH expression. POC has been achieved in a broad range of in vitro and in vivo models.

Vasculonics is developing a IV biomolecule for acute kidney injury and an oral molecule for diabetic kidney disease toward an IND filing for first in man studies, and is actively raising funds to achieve this goal.

Logo

MIDWEST DRUG DEVELOPMENT CONFERENCE
Bringing together industry and the best university drug development researchers in the Midwest
An Online Event
Oct. 4-5, 2021

Latest News
  • Presentation schedule set for 2021 September 21, 2021
  • MWDD moves to a virtual event in 2021 August 17, 2021
  • Sponsorship, presentation slots nearly full July 29, 2021
  • Registrations are now open for 2021 March 25, 2021
Twitter Hightlights
  • Today's the day!
    491 days ago
  • Schedule is set for the 2021 MidWest Drug Development Conference. Register today! https://t.co/5SvzL4EhuV
    504 days ago
  • No surprise to see some incredible innovations out of @UWMadison that could change drug delivery approaches, cancer… https://t.co/h90yfHwC5k
    505 days ago

Follow us! @DrugMw